A granulation screw is a machine for the production of […]
A granulation screw is a machine for the production of powdered pharmaceuticals. This machine has two feeders: one for the API and one for the filler. It feeds the API and filler in different ratios to achieve proper agglomeration. The design of the extruder barrel should include different proportions of filler and water to ensure proper granulation.
A typical granulation screw makes use of the extruder's melting mechanism to enhance the efficiency of the process. The motor supplies most of the energy required for melting the polymer, and electric heaters maintain the barrel temperature. A cooling channel is also included in the barrel to reduce the temperature of the melt.
The screw barrel configuration for granulation of powder materials offers a variety of benefits over traditional granulators. The screw can introduce fluid at a controlled rate throughout the granulation process, which provides spatial control and mixing capabilities. It also facilitates high-drug-loading compounding, enabling use of minimal excipients.
The speed of a granulation screw barrel can be controlled to reduce the time required for granulation of a given powder. Some studies have shown that higher screw speeds result in larger granules. Others have found no effect. It is important to know how to balance the two variables to optimize granulation.
The speed of a granulation screw barrel must be matched to the Tg of the polymer being processed. The speed of the screw also affects particle size distribution. Increasing the speed of a granulation screw barrel leads to a higher particle size with lower particle size distribution.